Rabbit monoclonal antibody services are high-affinity, highly specific immunoglobulins generated from one individual B lymphocyte clone and recognize a single epitope. They offer superior performance compared to traditional mouse monoclonal antibodies in terms of sensitivity, lot-to-lot consistency, and applications coverage.
Broader Antigen Recognition Capabilities
Due to unique processes, rabbits have a more expansive antibody repertoire than mice. The natural maturation of the rabbit immune system enables greater diversity in the primary antibody repertoire, allowing for greater chance of finding monoclonal antibodies with desirable epitope specificities.
This is largely attributed to the larger size of rabbits, which results in greater spleen and bone marrow tissue for B cells to proliferate and mature. The broader epitope recognition abilities of rabbits are also a result of their immune systems’ ability to mount robust responses against small molecules, peptides, and subtle structural differences such as post-translational modifications (phosphorylation, acetylation, and methylation).
Consequently, rabbit monoclonal antibodies can be used in a variety of applications including research, diagnostics, and therapeutics. For example, RabMAbs can be used to detect disease biomarkers and develop therapeutic agents for cancer, infectious diseases, autoimmune diseases, and inflammatory disorders.
Sino Biological offers a wide range of high-quality custom rabbit monoclonal antibody services, including ELISA, WB, IHC, ChIP, cell-based assays, and affinity ranking. The high-affinity and specificity of recombinant rabbit monoclonal antibodies makes them a valuable alternative to polyclonal antibodies for research, diagnostics, and therapeutic applications. Our recombinant rabbit monoclonal antibody services are based on phage display technology, a process that yields high-quality antibodies with consistent performance.